rious studies have shown that IgM and IgG class of antibodies can be detected almost simultaneously in the early phase of Covid 19 infection. During the acute phase of infection, the titer of IgM & IgA antibodies to SARS-CoV-2 rises rapidly and IgA antibodies peaks around22dayswhileIgMantibodiespeaksaround14days.TheIgGantibodiestoCovid19appeararound14-15days and maypersist for 6 months or more.The detection of total antibodies (IgM, IgG & IgA) to SARS-Covid-2 virus provides the improved sensitivity and better tool for screening and following up an acute or recent infection. Signal to noise ratio of RT- PCR con???rmed Covid positive samples is high in double recognition sandwich ELISA as compared to Covid IgM or Covid IgG differential ELISA tests kit. Detection of IgM, IgG & IgA antibodies to Covid 19 antibodies are useful in:??? Providinginformationfordiseaseprevelance??? Frequencyofasymptomaticinfection??? Identi???cation of potential donor for convalescent plasma??? To test the susceptibility or resistance to subsequent re-infection.??? Toperformepidemiologicalandsurveillancestudies??? Totrackthespreadofvirus.